photo

Contact Details

Forschungszentrum Jülich
ICS-6: Structural Biochemistry
52425 Jülich, Germany
Telefon: +49-2461-61-9532

Curriculum Vitae

January 2014 - Present
Postdoctoral Researcher in the Computational Biochemistry Group at the ICS-6: Structural Biochemistry, Jülich Research Center; Jülich Germany.

2012 - 2013
Postdoctoral Researcher at the Department of Chemical Informatics, University of Szeged; Szeged, Hungary.

2011 - 2012
Research Associate at the Material's Science Research Institute (MSRI) in the Semmelweis Dental School, Semmelweis University; Budapest, Hungary.

2010 - 2012
Ph.D. In Chemistry, under the direction of Dr. Béla Viskolcz, Department of Chemical Informatics, University of Szeged; Szeged, Hungary.

2007 - 2010
Report Writer at Pharma Medica Research Inc; Mississauga, Canada; Medical Writer at BioPharma Services Inc.; Toronto, Canada.

2003 - 2007
M.Sc. in Bio-Organic Chemistry, Department of Biomedical Sciences, Creighton University Medical School, Creighton University; Omaha, USA.

1998 - 2003
B.Sc. In Biochemistry, Department of Chemistry, Trent University; Peterborough, Canada.

Research Interests

  • Mechanisms of oxidative-stress induced toxicity in Alzheimer's disease.
  • Structural effects of free-radical induced oxidation on peptides and lipids.
  • Protein aggregation in amyloid diseases.
  • Utilizing computational chemistry techniques, ranging from first principle's approaches to coarse-grained molecular dynamics, to solve problems of physiological significance.

Publications

Conformational Transitions of the Amyloid-β Peptide Upon Copper(II) Binding and pH Changes.
Q. Liao, M. C. Owen, O. O. Olubiyi, B. Barz, & B. Strodel
Israel J. Chem., DOI: 10.1002/ijch.201600108 (2017) [link]

Radical Formation Initiates Solvent-Dependent Unfolding and β-Sheet Formation in a Model Helical Peptide
M. C. Owen, B. Strodel, I. G. Csizmadia & B. Viskolcz
J. Phys. Chem. B, DOI: 10.1021/acs.jpcb.6b00174 (2016) [link]

An account of amyloid oligomers: facts and figures obtained from experiments and simulations
L. Nagel-Steger, M. C. Owen, and B. Strodel
ChemBioChem, DOI: 10.1002/cbic.201500623 (2016) [link]

Impairment of a Model Peptide by Oxidative Stress: Thermodynamic Stabilities of Asparagine Diamide Cα-Radical Foldamers.
K. Z. Gerlei, L. Élő, M. C. Owen, I. Jákli, S. J. K. Jensen, I. G. Csizmadia, A. Perczel, B. Viskolcz.
Chemical Physics Letters 593, 104–108 (2014).

The Development of Alanyl Radical Parameters for the OPLS-AA Force Field.
M. C. Owen, L. Toth, B. Jojárt, I. Komáromi, I. G. Csizmadia and B. Viskolcz.
Journal of Chemical Theory and Computation 8, 2569-2580 (2012).

Conformation-Dependent OH/H2O2 Hydrogen Abstraction Reaction Cycles of Gly and Ala Residues: A Comparative Theoretical Study.
M. C. Owen, M. Szőri, I. G. Csizmadia, and B. Viskolcz.
Journal of Physical Chemistry B 116, 1143-1154 (2012).

Quantum Chemical Analysis of the Unfolding of a Penta-Glycyl 310-Helix Initiated by HO, HO2 and O2-•.
M. C. Owen, B. Viskolcz, and I. G. Csizmadia.
Journal of Chemical Physics 135, 035101 (2011).

Quantum Chemical Analysis of the Unfolding of a Penta-Alanyl 310-Helix Initiated by HO, HO2 and O2-•.
M. C. Owen, B. Viskolcz, and I. G. Csizmadia.
Journal of Physical Chemistry B 115, 8014-8023 (2011).

Conformational and Thermodynamic Analysis of the COXIB Scaffold Using Quantum Chemical Calculations.
M. C. Owen, M. Szőri, B. Jojárt, I. G. Csizmadia and B. Viskolcz.
International Journal of Quantum Chemistry 112, 922-936 (2012).

Development of glycyl radical parameters for the OPLS-AA/L force field.
I. Komáromi, M. C. Owen, R. F. Murphy, S. Lovas.
Journal of Computational Chemistry 29, 1999-2009 (2008).

Aromatic-Backbone Interactions in Model α-Helical Peptides.
N. Y. Palermo, J. Csontos, M. C. Owen, R. F. Murphy, S. Lovas.
Journal of Computational Chemistry 28, 1208-1214 (2007).

The Conformational Preference of Cα-Centered Radicals in Proteins.
M. C. Owen, I. Komáromi, R. F. Murphy, S. Lovas.
Journal of Molecular Structure. (Theochem) 759, 117-124 (2006).

Bridging the Gap Between Pure Science and the General Public: Comparison of the Informational Exchange for These Extremities for Scientific Awareness.
T. A. Pecora, M. C. Owen, C. N .J. Marai, D. H. Setiadi, G. A. Chass.
Journal of Molecular Structure. (Theochem) 666-667, 699-706 (2003).