Head: Jun.-Prof. Dr. Birgit Strodel
ICS-6: Structural Biochemistry
In our group we develop multiscale methods that bridge from the atomistic (microscopic) to a coarser (mesocopic) level for the description of biomolecules. Such methods enable us to reach mesoscopic time- and length scales in our simulations investigating biomolecular self-assembly. Here, our focus is on protein aggregation and the protein-protein interactions driving this process.
Within the variety of protein aggregation processes we currently concentrate on amyloid aggregation, which plays a major role in amyloid diseases, such as Alzheimer's disease.
Membrane permeation induced by aggregates of human islet amyloid polypeptides
C. Poojari, D. Xiao, V. S. Batista and B. Strodel.
Amyloid aggregation inhibitory mechanism of arginine-rich D-peptides
O. Olubiyi et al.
Curr. Med. Chem. (accepted)